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Pharmaceutical Care and Research: 2017; 17(4):254-257,266
DOI: 10.5428/pcar20170404
Quality evaluation of betamethasone tablets by probabilistic model
1. WU Long1(1.Undergraduate of Grade 2013,School of Pharmacy,Guangxi Medical University,Nanning 530021,China
2. GONG YiHua1(1.Undergraduate of Grade 2013,School of Pharmacy,Guangxi Medical University,Nanning 530021,China )
3. LIN Hua2(2.Department of Food,Liuzhou Institute for Food and Drug Control of Guangxi Zhuang Ethnic Autonomous Region,Guangxi Liuzhou 545000,China )
4. HUANG XingZhen1(1.Undergraduate of Grade 2013,School of Pharmacy,Guangxi Medical University,Nanning 530021,China
ABSTRACT  Objective: To investigate the quality of betamethasone tablets produced by different manufacturers by probabilistic model,so as to provide reference for the establishment of the drug quality grading evaluation system.Methods: A mathematical model was established based on the principle of ideal point method and the concept of normal distribution.The 3 detection parameters(drug content,content uniformity and dissolution ) of betamethasone tablets as the measurement results were converted to space coordinates.The perfect ideal parameter was regarded as an ideal space point theoretically,and the standard qualified parameter of the drug was regarded as the lower limit space point.After translating the subordination of angle included in the multi-dimensional space vector into evaluation parameters,the evaluation grade was appraised by variance analysis and calculated by using the normal distribution model of probability theory and mathematical statistics to obtain further comprehensive evaluation results.Results: According to the result of ANOVA analysis,there were no significant differences in the comprehensive evaluation results of betamethasone tablets produced by different manufacturers (P>0.05),indicating that the overall quality of betamethasone tablets was good.Analysis of evaluation parameters distribution indicated that manufacturer A could offer greater potential to get better betamethasone tablets.Conclusion: The mathematical model could play an important role in the evaluation of the quality grade of the drugs and the grade of the drug manufacturers.The method is practical and worth further spreading.
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WU Long1,GONG YiHua1,LIN Hua2,HUANG XingZhen1,. Quality evaluation of betamethasone tablets by probabilistic model[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(4): 254-257,266.
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