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Pharmaceutical Care and Research: 2017; 17(4):275-278
DOI: 10.5428/pcar20170409
Development of chimeric antigen receptor T cell products and challenges encountered in clinical application
1. WANG Chong(Shanghai Center for Drug Evaluation and Inspection,Shanghai 201203,China
ABSTRACT  Chimeric antigen receptor T cell(CAR-T) products have achieved obvious effects in tumor immunotherapy.CAR-T cell therapy has shown high objective response rates,especially in the patients with B lymphocyte malignance.The feasibility of industrial production,choice of viral vector,challenges encountered in clinical application and strategies for the development of CAR-T cell products were reviewed in the paper.
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WANG Chong,. Development of chimeric antigen receptor T cell products and challenges encountered in clinical application[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(4): 275-278.
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