Your Navigation:PCAR > Abstract
Search pcar
Pharmaceutical Care and Research: 2017; 17(4):283-286,307
DOI: 10.5428/pcar20170411
Progress of the determination methods and pharmacokinetics of Schisandra chinensis lignans
1. LI Jie1(1.Department of Pharmacy,Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China
2. HU JinHong2(2.Department of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai 200433,China
ABSTRACT  There are a variety of structurally similar lignans in Schisandra chinensis raw materials.The paper made a comprehensive review on the determination methods of Schisandra chinensis ligans and research progress of pharmcokinetics,so as to know the most commonly used determination methods and regular pattern of lignan metabolism in the body,and also to provide evidence for the determination of Schisandra chinensis lignans,speculation of the relationship between effective component dosage and time,and quantitative description of the pattern of in vivo metabolism of the drug.
Welcome to PCAR! You are the number 47 reader of this article!
Please cite this article as:
LI Jie1,HU JinHong2,. Progress of the determination methods and pharmacokinetics of Schisandra chinensis lignans[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(4): 283-286,307.
1. State Pharmacopoeia Committee.Pharmacopoeia of the People’s Republic of China.2015 ed.Volume 1[S].Beijing:China Medical Science Press,2015:66-67.In Chinese.
2. WANG BaoLian.Study on pharmacokinetics and metabolism of Fructus Schisandrae chinensis[D].Beijing:Beijing Union Medical College,2009.In Chinese with English abstract.
3. Ono H,Matsuzaki Y,Wakui Y,et al.Determination of schizandrin in human plasma by gas chromatography-mass spectrometry[J].J Chromatogr B,1995,674:293-297.
4. XIA YongGang,YANG BingYou,LIANG Jun,et al.Quantitative analysis and fingerprint profiles for quality control of fructus Schisandrae by gas chromatography: mass spectrometry[J].Sci World J,2014,2014:ID 806759.
5. DOU ZhiHua,DING AnWei,WANG LuJun,et al.Serum pharmacochemistry of compound Wurenchun capsules[J].Chin Tradit Herbal Drugs,2006,37(8):1137-1140.In Chinese with English title.
6. AN Yu,LI JuAn,DING Yan.Determination of serum concentrations of deoxyschizandrin by RP-HPLC[J].Chin Pharmacy,2007,18 (36):2849-2850.In Chinese with English abstract.
7. WU ZhiHeng,QI Wei,CHEN Hong,et al.Determination of deoxyschizandrin in rat’s plasma by HPLC[J].Acta Acad Med CPAPF,2007,16 (4):354-356.In Chinese with English abstract.
8. WEI BinBin,CHEN XiaoHui,SU Dan,et al.Pharmacokinetics of deoxyschizandrin and γ-schizandrin of Schisandra chinensis oil in rats[J].Chin Hosp Pharm J,2010,30 (9):755-758.In Chinese with English abstract.
9. MA XiaoLin,CHEN DaoFeng.Pharmacokinetic study of schisanhenol via femoral introvenous administration in rats[J].Chin Tradit Herbal Drugs,2010,41 (2):216-219.In Chinese with English abstract.
10. GUAN Jiao,ZHU HeYun,ZHANG XiuRong,et al.Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice[J].J Chin Med Mater,2011,34 (12):1912-1915.In Chinese with English abstract.
11. WU ChunTao,LIU TieNan,ZHANG ZhiFei.Study on a HPLC method for the determination of γ-schizandrin in rat plasma[J].J North China Coal Med Coll,2011,13 (3):310-311.In Chinese with English abstract.
12. DENG Chong,ZHENG Jie,DONG YuanYuan,et al.Effects of steaming orange magnoliavine fruit with vinegar on pharmacokinetics in rats[J].Chin J Inf TCM,2014,21 (7):81-84.In Chinese with English abstract.
13. ZHAO ZhenYu,ZHANG ChengYi,SHENG Yu.Distribution characteristics of schisandrin A and schisandrin B in mouse tissues[J].Chin J Pharm Anal,2015,35(10):1764-1769.In Chinese with English abstract.
14. LIU MinYan,ZHAO ShaoHua,WANG ZongQuan,et al.Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques[J].J Chromatogr B,2014,949-950:115-126.
15. XU MeiJuan,WANG GuangJi,XIE HaiTang,et al.Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies[J].J Chromatogr B,2005,828(1-2):55-61.
16. DENG XinXiu,CHEN XiaoHui,YIN Ran,et al.Determination of deoxyschizandrin in rat plasma by LC-MS[J].J Pharm Biomed Anal,2008,46(1):121-126.
17. WANG BaoLian,HU JinPing,TAN Wei,et al.Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry[J].J Chromatogr B,2008,865(1-2):114-120.
18. WEI Hua.Study on the pharmacokinetics of Wuzhi-capsule and its herb-drug interaction with tacrolimus[D].Shanghai:Second Military Medical University,2010.In Chinese with English abstract.
19. ZHU HeYun,ZHANG XiuRong,GUAN Jiao,et al.Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry[J].J Pharm Biomed Anal,2013,78-79:136-140.
20. WEI BinBin,LI Qing,SU Dang,et al.Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats[J].J Pharm Biomed Anal,2013,77:120-127.
21. ZHANG Hai,ZHOU YanNi,SUN Sen,et al.HPLC-TOF/MS analysis of the metabolic rate and metabolites of three lignans in Schisandra chinensis (Turcz.) Baill in rat liver microsomes[J].Acad J Sec Mil Med Univ,2014,35(4):426-431.In Chinese with English abstract.
22. WANG Qing,WANG Ying,SONG XiaoMei,et al.Simultaneous determination of six lignan compounds in rat plasma and pharmacokinetics by UHPLC-MS/MS[J].Chin Tradit Patent Med,2014,36 (2): 266-271.In Chinese with English abstract.
23. LI HuiLian,JI De,MAO ChunQin,et al.Rapid detemination of three lignans in fruit of Schisandra chinensis by LC-MS and analysis of their pharmacokinetics in rat plasma[J].Chin Pharmacolog Bull,2013,29(9):1313-1317.In Chinese with English abstract.
24. ZHOU Yuan,MAO ChunQin,HU JunYang,et al.Tissue distribution of schisandrin,deoxyschisandrin and schisandrin B in rats determined by HPLC-MS[J].Chin J Pharm Anal,2013,33 (7):1121-1126.In Chinese with English abstract.
25. Ikeya Y,Sugama K,Tanaka M,et al.Structure determination of biliary metabolites of schizandrin in rat and dog[J].Chem Pharm Bull (Tokyo),1995,43(1):121-129.
26. WANG Wei,TIAN DanDan,ZHANG ZhangJin.In vitro effects of concomitant use of herbal preparations on cytochrome P450s involved in clozapine metabolism[J].Molecules,2016,21(5):597-605.
《药学服务与研究》杂志社 All Rights Reserved 网站备案号:鲁B2-20061008
·地址:上海市杨浦区长海路168号18号楼东三楼 邮政编码:200433
·联系电话(传真):86-21-65519829, 021-31162330