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Pharmaceutical Care and Research: 2017; 17(4):310-313
DOI: 10.5428/pcar20170419
Retrospective analysis of 127 cases of drug eruptions
1. XIN RuJuan(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China [email protected])
2. CHEN ZhongJian(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
3. LI Ying(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
4. SHEN Min(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
5. ZHU QuanGang(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China [email protected])
ABSTRACT  Objective: To explore clinical features of the patients with drug eruptions,causative drugs and therapy,so as to provide reference for rational medication and reduction of drug eruptions.Methods: The clinical data of 127 patients with drug eruptions hospitalized in Shanghai Hospital of Skin Diseases from December 2014 to December 2016 were collected and a retrospective analysis was made for the study.Results: The drugs that induced drug eruptions were mainly antibacterials (57 cases,44.9%),traditional Chinese herbal medicine and their preparations (22 cases,17.32%) and antipyretic analgesics (20 cases,15.8%),respectiuely.Urticarial drug eruptions (63 cases,49.61%) was the most common type of drug eruptions,followed by exanthesis (29 cases,22.83%) and erythema multiforme (18 cases,14.18%).Of the 119 cases of non-severe drug eruptions,there were 109 cases with hematological abnormality,42 cases with liver or kidney dysfunctions.Of the 8 cases of severe drug eruptions,there were 7 cases with hematological abnormality and 5 cases with liver or kidney dysfunctions.Conclusion: The most common types of drug eruptions were urticarial and exanthesis eruptions,and the main causative drugs were antibacterials,traditional Chinese herbal medicine and their preparations.Pharmaceutical monitoring of those allergic drugs should be strengthened and awareness of safe medication should be enhanced,so as to minimize the incidence of drug eruptions.
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XIN RuJuan,CHEN ZhongJian,LI Ying,SHEN Min,ZHU QuanGang,. Retrospective analysis of 127 cases of drug eruptions[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(4): 310-313.
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