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Pharmaceutical Care and Research: 2017; 17(4):310-313
DOI: 10.5428/pcar20170419
Retrospective analysis of 127 cases of drug eruptions
1. XIN RuJuan(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China
2. CHEN ZhongJian(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
3. LI Ying(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
4. SHEN Min(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China )
5. ZHU QuanGang(Department of Pharmacy,Shanghai Hospital of Skin Disease,Shanghai 200443,China
ABSTRACT  Objective: To explore clinical features of the patients with drug eruptions,causative drugs and therapy,so as to provide reference for rational medication and reduction of drug eruptions.Methods: The clinical data of 127 patients with drug eruptions hospitalized in Shanghai Hospital of Skin Diseases from December 2014 to December 2016 were collected and a retrospective analysis was made for the study.Results: The drugs that induced drug eruptions were mainly antibacterials (57 cases,44.9%),traditional Chinese herbal medicine and their preparations (22 cases,17.32%) and antipyretic analgesics (20 cases,15.8%),respectiuely.Urticarial drug eruptions (63 cases,49.61%) was the most common type of drug eruptions,followed by exanthesis (29 cases,22.83%) and erythema multiforme (18 cases,14.18%).Of the 119 cases of non-severe drug eruptions,there were 109 cases with hematological abnormality,42 cases with liver or kidney dysfunctions.Of the 8 cases of severe drug eruptions,there were 7 cases with hematological abnormality and 5 cases with liver or kidney dysfunctions.Conclusion: The most common types of drug eruptions were urticarial and exanthesis eruptions,and the main causative drugs were antibacterials,traditional Chinese herbal medicine and their preparations.Pharmaceutical monitoring of those allergic drugs should be strengthened and awareness of safe medication should be enhanced,so as to minimize the incidence of drug eruptions.
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XIN RuJuan,CHEN ZhongJian,LI Ying,SHEN Min,ZHU QuanGang,. Retrospective analysis of 127 cases of drug eruptions[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(4): 310-313.
1. Bolognia J L,Jocizze J L,Rapini R P.Dermatology[M].2nd ed.Translated by ZHU XueJun,WANG BaoXi,SUN JianFang,et al. Beijing: Peking University Medical Press,2015:348.In Chinese.
2. ZHAO Bian.Chinese clinical dermatology[M].Nanjing: Jiangsu Science and Technology Press,2009: 751-761.In Chinese.
3. CHEN XinQian,JIN YouYu,TANG Guang.New materia medica[M].17th ed.Beijing: People’s Health Press,2011: 2-14.In Chinese.
4. HU YuXia,NONG Xiang,LEI DongYun,et al.Retrospective analysis of hospitalized patients with drug eruption in six years[J].J Dermatol Venereol,2016,38(4):245-249.In Chinese with English abstract.
5. WEN TingQi. Clinical analysis of pathogenesic drugs in hospitalized patients with drug eruption[J].China Foreign Med Treat,2016,10(34):145-147.In Chinese with English abstract.
6. Sushma M,Noel M V,Ritika M C,et al.Cutaneous adverse drug reaction: a 9-year study from a South Indian Hospital[J].Pharmacoepidemiol Drug Saf,2005,14 (8):567-570.
7. XU KeMing.Adverse drug reaction analysis of traditional Chinese medicine injections and their reasonable application[J].Tianjin J Tradit Chin Med,2016,33(7):411-413.In Chinese with English abstract.
8. TAO SiJing,WU JianBo,ZHANG SongSong,et al.Analysis of 314 cases of drug eruption induced by allopurinol[J].Guide China Med,2013,11(8):85-87.In Chinese.
9. Arndt C,Hawkins D,Anderson J R,et al.Age is a risk factor for chemotherapy-induced hepatopathy with vincristine,dactinomycin and cyclophosphamide[J].J Clin Oncol,2004,22(10):1894-1901.
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